Victor Boniface scored his first European goal of the season as Xabi Alonso’s side defeated Samuel Chukwueze’s AC Milan 1-0 at the Bay Arena, giving Bayer Leverkusen a back-to-back win.
The Nigeria international thought he had given the German champions the lead before half-time, but it was canceled out by VAR.
However, six minutes into the second half, Jeremy Frimpong set him up and he scored the winning goal.
Milan’s crosstown rivals Inter beat underdogs Crvena Zvezda 4-0 at San Siro, scoring their first of the season with goals from Hakan Calhanoglu, veterans Marko Arnautovic and Lautaro Martinez. won.
Meanwhile, Robert Lewandowski launched a flurry of attacks early in both halves as Barcelona bounced back from their opening game loss to Monaco by defeating Young Boys 5-0.
PSV Eindhoven also earned their first point of the season with a 1-1 draw with Sporting Lisbon, with Dutch national team midfielder Jerdi Schouten scoring the opening goal and the visiting team equalizing in the final stages.
Stade Brest had never featured in the Champions League until this season.
In an early kick-off on Tuesday, the French team defeated Salzburg 4-0, with Senegalese forward Abdallah Sima scoring two goals for their second win in two games.
VFB Stuttgart drew 1-1 with Sparta Prague in their recent match.